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G Protein-Coupled Receptor Kinase in OA There are seven G protein-coupled receptor kinase (GRKs) subtypes, relevant to the role in GPCR phosphorylation and desensitization, and also phosphorylation of a number of intracellular signaling proteins

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It is a central regulator of immune and inflammatory responses ( Figure 3 ) ( Figure 3 Additionally, the activation of NF-B leads to increased expression of key genes, including proinflammatory cytokines like IL-6, IL-8, IL-16, and TNF-, which contribute to inflammation