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Leach et al., 2021)
These models use vast datasets of known protein structures and binding assays to predict how a novel sequence will behave
Therefore, because P14ARF gene deletion already renders P53 effectively obsolete in combating cancer, DINO production is not disrupted by the cancer cell
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Taken together with precedent from oncology, the overall evidence indicates that Erastin has clear therapeutic potential for EMS, provided drug delivery preferentially targets lesions while sparing healthy tissue
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