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High-throughput phenotyping Importantly, the integration of CRISPR screening with high-content phenotyping modalities, including live-cell imaging, multiplex transcriptomics, and single-cell RNA sequencing, enables real-time visualization of how cells dynamically reorganize proteostasis resources

First, we characterized the mechanism of cell death observed in GSH-depleted RPE through a series of functional measurements

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Native GLP-1, for example, has a half-life of only about 1 to 2 minutes