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Effect of GS on expression of COX-1, COX-2, and mPGES-1 in OA chondrocytes Since COX-1, COX-2, and mPGES-1 are the major enzymes involved in production of PGE 2 , we next examined at which level the effect of GS was attributable

In animal studies, it suppresses appetite and reduces body weight with effect sizes that are, in early reads, comparable to the GLP-1 class

SGLT2is decrease plasma glucose levels by inhibiting renal reabsorption in the proximal tubule by increasing renal excretion of glucose

The eyes lens becomes less flexible as we age so it can take longer to stabilize when the body experiences changes in blood sugar levels

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