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After an acute kidney injury (AKI) event, when kidney function suddenly falls close to or below the level necessary to sustain life, acute hyperkalemia results, worsened by metabolic acidosis
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Unlike some medications that can be frozen for long-term storage, tirzepatide's peptide structure is damaged by ice crystal formation
Ji L, Gao L, Jiang H, et al
The prescriber should document the rationale for escalation in the clinical record, consistent with best practices for off-label weight-loss drug management [14]
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