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76 Studies have shown that within various cell types, including vascular smooth muscle cells, endothelial cells, adipocytes, hepatocytes, pancreatic islet cells, and renal tubular cells, uric acid can activate NADPH oxidase, a crucial enzyme involved in the generation of reactive oxygen species
Mast cell function: a new vision of an old cell
doi: 10.1038/s41569-022-00771-0 174 AguilarECDos SantosLCLeonelAJDe OliveiraJSSantosEANavia-PelaezJMet al
We also tested whether the intracellular amino acid target mTOR (mammalian target of rapamycin) played a role [35], by addition of 100 ng/ml rapamycin
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