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Any receptor that is stimulated continuously tends to become less responsive over time it down-regulates

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Khan NA, Westfall DR, Jones AR, et al

Albeit small, its two to three month increase in survival time (Miller 2007) indicates that controlling glutamate levels in the brain could be an essential component in fighting ALS and provides valuable information toward ultimately finding a more effective treatment for the disease (Carlesi 2011)

Gut microbiota-induced immunoglobulin G controls systemic infection by symbiotic bacteria and pathogens