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10.1517/13543784.2015.1051617 136 ShenolikarS.VoltzJ

It would appear from our findings that the minimum adequate intake values determined in a VA setting in older people by Tuttle et al [6] may closer to being accurate than those currently accepted as the RDA

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Collectively, these clinical observations highlight that isoform-specific targeting is essential not only for efficacy but also for minimizing off-target side effects, emphasizing the need for early-stage ADME/PK and selectivity profiling in the development of novel dual PDE1B/PDE10A inhibitors