for more details, see Sampson et al., 2021 13
Current Evidence: GLP-1 Effects on Rheumatoid Arthritis Symptoms As of 2025, there is limited direct clinical evidence examining the effects of GLP-1 receptor agonists specifically on rheumatoid arthritis symptoms or disease progression
In melanoma patients refractory to antiPD-1 therapy, the combination of Talimogene laherparepvec (T-VEC), an oncolytic herpesvirus, with pembrolizumab (NCT04068181) showed enhanced systemic immune activation and tumor response
Similarly, 6% of respondents said they were interested in taking a GLP-1 but weren't
This is clearly demonstrated in people living with DS, where the overexpression of CBS is a genetic consequence that causes a significant reduction of serum homocysteine concentration leading to less available methionine within the methionine cycle