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Gln is catalyzed by glutaminase to generate -ketoglutarate (-KG), which can directly feed into the TCA cycle
Lidia Malaty, PharmD
She emphasised on the use of ceramides and called it a hero ingredient
The Phase 2 NEJM trial mapped this relationship across four dose tiers, and the Phase 3 TRIUMPH-4 data confirmed it at scale (Jastreboff et al., NEJM, 2023)
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