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Thus, it can be summarized that morphological alterations typical of eryptosis, including cell shrinkage and membrane microvesiculation, are governed by the elevation of intracellular calcium ion levels

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Receptor endocytosis, an intermediate step toward downregulation, is also necessary for resensitization via dephosphorylation and recycling 11, thus, totally inhibiting endocytosis will likely result in reduced signaling as surface receptors become desensitized via -arrestin recruitment