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A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II) The COR-II study found that naltrexone/bupropion (NB32) significantly improved weight loss, cardiometabolic risk markers, and eating control in overweight and obese participants, with mild to moderate nausea as the main side effect and no increased risk of depression or suicidality

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