The head-to-head data is equally decisive
Here's what's happening at the cellular level: Immune System Modulation : GLP-1 receptors are expressed on circulating T and B lymphocytes, human invariant natural killer T cells, and immature lymphocyte subsets, highlighting their role in lymphocyte maturation and regulatory T-cell functioning
Tirzepatide, a dual GLP-1/GIP receptor agonist approved as Mounjaro for diabetes and Zepbound for weight management, has demonstrated superior efficacy compared to semaglutide in head-to-head trials (SURPASS-2 for diabetes
Biochemical analyses on day eight measured liver function markers (alanine transaminase, aspartate transaminase, alkaline phosphatase , bilirubin, total protein, and albumin) and oxidative stress indicators (glutathione and malondialdehyde)
They bind to receptors on cell surfaces and trigger cascades of biological responses