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This gap matters because the assumptions underlying microdosing, that lower starting doses reduce side effects while preserving the gradual receptor adaptation that makes titration effective, remain assumptions
Zorn S, Bounds R, Williamson A, et al
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Our results showed that incorporating the lipid tail into the membrane center is favorable overall ( G = 5.0 kcal mol 1 )
Patience during the lower-dose titration period is essential
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