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doi:10.3389/fendo.2020.00365 39

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Ultra-flexible liposomes Ultra-flexible liposomes such as transferosomes, ethosomes, and transethosomes possess high elasticity, enabling them to penetrate skin layers easily and deliver drugs to the desired site without any drug loss, enhancing bioavailability and therapeutic efficacy while decreasing their side effects [125]

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112,113 In metastatic hormone receptorpositive breast cancer, mutations in the ligand-binding domain (LBD) of estrogen receptor 1 (ESR1), which encodes ER, contribute to treatment resistance