This is complemented by the incretin effect, insulin-sensitising properties, and promotion of subcutaneous fat accumulation mediated by GIP, as well as the thermogenic and lipolytic actions of GCG (Table 2).54 Its structure resists degradation by DPP-4 and enables binding to albumin, resulting in a half-life of six days, which allows for once-weekly subcutaneous administration
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In humans, neuroimaging studies show associative evidence that GLP-1 agonists alter brain responses to food cues, potentially dampening the neural reactivity to appetizing foods that may trigger binge episodes in susceptible individuals
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