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ice crystal formation disrupts the peptide backbone
The Month 2 dose increase is data-driven, not arbitrary
While the exact mechanisms through which GLP-1 RAs contribute to weight loss are still under investigation, it is believed that they interact with the central and peripheral nervous systems, reducing appetite and food intake
Pioglitazone A thiazolidinedione that improves insulin sensitivity
In a study that compared the effects of SCS and placebo for 6 months in 60 patients with DPN refractory to medical therapy, the VAS score decreased significantly only in the SCS group (Table 2) [101]
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