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Uncontrolled hypertension despite treatment with two or more antihypertensive medications "Uncontrolled" generally means a systolic blood pressure consistently above 140 or a diastolic above 90 despite ongoing treatment with at least two antihypertensive medications from different drug classes (such as an ACE inhibitor or ARB, a calcium channel blocker, a thiazide diuretic, or a beta-blocker)
This reduces oral bioavailability from 2030% to an estimated 1218%
Operating expenses totaled $18.7 billion, an increase of $1.6 billion (9%) over 2022, reflecting increases in medical claims ($364 million or 51%, related to the increase in Health Plan membership), wages ($543 million or 8%, including market adjustments for certain employees and ongoing use of temporary staffing), costs and use of clinical ($127 million or 14%) and pharmaceutical ($320 million or 26%) supplies, and depreciation and interest ($9 million, 1%)
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Basu, A., Patel, N
