The most frequently reported NAEs included dizziness (n = 7,078), tremor (n = 2,519), dysgeusia (n = 1,469), lethargy (n = 783), taste disorder (n = 482), presyncope (n = 370), allodynia (n = 192), and parosmia (n = 192) (Fig
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Providing adolescents with obesity another option Wegovy is the only once-weekly injectable GLP-1 RA indicated to reduce excess body weight and maintain weight reduction long term in combination with diet and exercise in adolescents with obesity aged 12 years and older 3 The safety and effectiveness of Wegovy injection have not been established in pediatric patients to reduce the risk of major adverse CV events or to reduce excess body weight and maintain weight reduction long term in those less than 12 years of age
Two additional areas that may be ripe for future patent-related litigation challenges involving GLP-1 drugs include patent infringement claims brought against compounding pharmacies and claims challenging whether patents are properly listed in the Orange Book for certain GLP-1 drugs
The concern arises from the potential impact of ibuprofen on renal function, which could indirectly influence the pharmacokinetics of semaglutide and its glucose-lowering effect