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H152 and active site residues C46, K48, Q81, and W136 are highlighted and shown as sticks

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1,2 This review evaluates the proposed mechanisms of action of GLP-1RAs, critically analyses recent evidence from clinical trials and considers the optimal clinical use of GLP-1RAs and potential future directions

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Cell apoptosis analysis Apoptosis was assessed by flow cytometry using a KeyGEN Annexin V-FITC Apoptosis Detection Kit (KeyGEN BioTECH, China) according to the manufacturers instructions

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