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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

doi: 10.1016/j.bbagen.2012.10.005 96 GargS

Unlike other neuropeptides such as ghrelin or oxytocin, for which specific genes and high-affinity receptors have been cloned and characterized, the genomic origin of DSIP and its specific receptor target remain elusive in the human genome

Also Read: Top 5 Amazing Benefits Of Sunflower Seeds For Skin Now, this spice is very important in the Indian diet for both dietary and medicinal purposes

This practice limits the ability to confirm whether a specific product batch was independently tested