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Regulatory agencies like the FDA require strong safety databases for drugs that will be prescribed to millions of people, and a trial of this size provides the statistical power needed to detect both efficacy signals and uncommon adverse events

Progress celebration for achieving milestones and maintaining consistency helps sustain motivation during periods when benefits may be less apparent or dramatic

This provides deep exfoliation to target hyperpigmentation and fine lines, rejuvenating the skin with lasting results

Severe cases can develop into chronic ulcers, strictures, and even perforations, significantly impacting patients quality of life and treatment compliance [4,5,6]

Additionally, gender differences in hormonal balance and body composition may affect how well these medications work for individual patients