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331 Ginkgo biloba B, a principal component of Ginkgo biloba extract, reduces hepatic lipid accumulation and ameliorates MAFLD in obese mice
It was identified through a medicinal chemistry programme at the University of Texas Health Science Center as the lead NNMT inhibitor candidate among a series of 1-methylquinolinium analogues bearing primary amine substitutions, selected for its combination of high passive membrane permeability (confirmed in PAMPA assays), high active transport membrane permeability (confirmed in bidirectional Caco-2 cell assays), potent NNMT inhibitory activity, and high selectivity including confirmed absence of inhibitory effects on related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway
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Highlighting the cooperative state of the microbiota and the innate mucosal immune system is crucial
Vajdi, M., & Farhangi, M
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