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By targeting multiple mechanismssuch as enhancing insulin secretion, suppressing glucagon release, slowing gastric emptying, and promoting satietyGLP-1 RAs provide significant improvements in glycemic control, weight reduction, and long-term cardiovascular and renal health (6)(16)(23)

Hyperglycemic clamp and stable-isotope infusions Twenty-week old C57Bl/6J DIO male mice (Jackson Laboratories) were dosed (~5 pm) with vehicle or cotadutide (10 nmol/kg), liraglutide (10 nmol/kg), or g1437 (10 nmol/kg) 2 h prior to lights out for 7 consecutive days ( n = 810)

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doi: 10.1001/jamapsychiatry.2023.2696