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These can range from minor issues like bloating, cramping, and allergic reactions, to more severe complications like kidney dysfunction and bronchial constriction, especially in asthmatic individuals

Although substantial weight loss can reduce pathological joint loading and systemic inflammation, the direct pharmacological effects on synovial fibroblastsattenuating their inflammatory signalling and fibrotic activation may offer an additional, disease-modifying and analgesic mechanism that targets the local synovial environment, driving pain and structural progression

Feimeng Zhou (University of Jinan)

Retatrutide (LY3437943) is an investigational triple-agonist (GLP-1, GIP, glucagon) and is not an approved therapy