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Feelings of nausea, a disrupted stomach, or diarrhea
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*J Physiol Paris.* 95(1-6):295-301
Blocking NNMT preserves the NAD+ precursor pool (1.2-1.6x increase in intracellular NAD+), increases SAM availability for epigenetic methylation, and activates SIRT1/SIRT3 signaling
Acute otitis media (middle ear infection) affects the eustachian tube's ability to equalize pressure, making chewing motions particularly painful due to increased pressure changes
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