They were subsequently found to have a profound impact on weight which is why they are now being marketed as weight loss medications
Daily oral dosing requires more consistent adherence than weekly injections, but eliminates injection anxiety for patients uncomfortable with needles
For nausea, patients should be advised to: Eat smaller, more frequent meals rather than three large meals Avoid lying down immediately after eating Choose bland, low-fat foods when symptoms are present Stay well-hydrated with clear fluids between meals Consider ginger tea or other non-pharmacological remedies If gastrointestinal side effects are intolerable, the prescribing physician may recommend extending the titration period, holding at the current dose, or stepping back to a lower dose temporarily
maintaining adequate fluid intake and seeking medical advice if symptoms are severe or prolonged is important
Safety and Efficacy of Exenatide once Weekly Plus Dapagliflozin once Daily Versus Exenatide or Dapagliflozin Alone in Patients with Type 2 Diabetes Inadequately Controlled with Metformin Monotherapy: 52-Week Results of the DURATION-8 Randomized Controlled Trial