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Poliovirus mutants at histidine 195 of VP2 do not cleave VP0 into VP2 and VP4
Oral peptide delivery has to solve gastric degradation and poor intestinal permeability before pharmacokinetics is even on the table, which is why oral semaglutide requires an absorption enhancer and a very different dose to reach comparable exposure
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Linker chemistry plays a critical role, where disulfide (SS) or diselenide (SeSe) bonds connect the drug to the carrier, enabling selective cleavage under reducing conditions
Dem wirkt Glutathion durch einen antioxidativen Schutzmechanismus entgegen
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