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DSIP administration did not significantly affect corticotropin-releasing-hormone (CRH)-stimulated or meal-induced ACTH and cortisol secretion, indicating thatcontrary to stress-protective effects reported in some animal studiesDSIP does not measurably blunt the human cortisol response
No food, beverage, or over-the-counter supplement has been shown to produce weight loss effects comparable to FDA-approved semaglutide or tirzepatide treatment
It is therefore not available as a licensed medicine in the UK outside of regulated clinical trials
Only 4.9% of the placebo group achieved this
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