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Oral semaglutide was generally well tolerated, with a safety profile consistent with that seen in the global PIONEER trials
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They work by mimicking a natural hormone, GLP-1, that your body naturally produces after eating to help control blood sugar and appetite
The broader receptor profile of these newer-generation GLP-1 receptor agonists is thought to offer clinical advantages, potentially providing better tolerability or enhanced effectiveness due to simultaneous modulation of reward-related neural circuits and metabolic pathways (Ray 2023
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