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For patients with eGFR between 30-45 mL/min/1.73 m, a careful reassessment of benefit-risk is recommended with consideration of dose reduction
A 24-hour urinary potassium excretion of less than 15 mmol or a potassium-creatinine ratio less than 1 suggests an extrarenal cause of hypokalemia
Nothing has been more earthshaking than the meteoric rise of GLP-1 drugs for weight loss in the health industry except perhaps one woman: Oprah Winfrey
Over-the-counter options include stool softeners or osmotic agents like polyethylene glycol when lifestyle steps fall short, but coordinate medication choices with your clinician if symptoms persist or if you use other constipating drugs
However, there is only one approved drug, setmelanotide for POMC-LEPR deficiency [10], and there is no treatment for other POMC-MC4R pathway-deficient diseases, such as POMC-null, MSH-deficiency, and patients with PWS with obesity
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