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It is well known that malonyl-CoA is the key regulator of LCFA oxidation in the heart because it is the physiological and potent inhibitor of CPT I which transports LCFA from cytoplasm into mitochondria [42,43,44,45]

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Meanwhile, molecular glues may directly bridge USP8 with E3 ubiquitin ligases through their unique mechanisms to form complexes, mediating more streamlined degradation

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Of course intracellular glutathione metabolism is affected by the import of amino acids and the export and removal of GSH and GSSG