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Tirzepatide produced 20.2% weight loss versus 13.7% for semaglutide at 72 weeks and has stronger body-composition results. Semaglutide has the longer safety history, cardiovascular outcomes data, kidney outcomes data, and an oral formulation. Oral semaglutide What about oral semaglutide (Rybelsus)
In older adults, hypoglycemia can be particularly dangerous: it can cause falls, confusion, fainting, and cardiac stress
Because the drug is still being studied, researchers are continuing to monitor potential long-term risks such as cardiovascular effects and pancreatic complications
Semaglutide was associated with the highest rate of cutaneous adverse effects while dulaglutide was associated with the lowest rate
Additionally, a 1-year training study in 155 older women demonstrated that not only was a single day of high intensity RT (2 sets of 6-8 repetitions at 70%85% of 1RM) per week sufficient to improve memory at the cessation of the study compared to pre-training, but these cognitive benefits persisted for 1 year after training compared to balance-and-toning controls (Best et al., 2015)
