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Smits, M
How long it takes varies from person to person and depends on the medication, the dose, and individual factors
Disadvantages: Requires an oral syringe for accurate measurement, technique-dependent (holding position, timing), taste can be unpleasant for some people, requires proper storage
Joint modeling approaches, which analyze biomarker trajectories and time-to-event outcomes together, further strengthen prediction and reduce bias when progression is variable or follow-up is incomplete (97, 98)
10.1093/oxfordjournals.bmb.a072259 33 EyreD
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