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LRRK2 and the endolysosomal system in Parkinsons disease
When a low dose of aspirin is administered orally (most commonly 81 mg), its context-sensitive drug disposition via the portal circulation combined with the difference in IC50 values for COX-1 vs COX-2 both contribute significantly to the high selectivity by which low dose oral aspirin inhibits platelet COX-1 vs other COX-2 found in other nucleated tissues such as the vascular endothelium (Pedersen & FitzGerald, 1984
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These implications have been described across endocrine signaling pathways, receptor localization patterns, and intracellular cascade activation profiles, without implying translational relevance
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