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Single doses of 42, 140, 420 and 1260 mg intravenously were well tolerated and showed dose-proportional, linear pharmacokinetics, with the half-life increasing with the dose Ruff et al., 2010
Oxidative Stress Testing
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Optimal Storage Conditions Lyophilized powder: -20C to -80C in freezer Reconstituted solution: 2C to 8C in refrigerator Protected from direct light exposure Sealed containers to prevent contamination Upright positioning in storage Storage Duration Guidelines Unopened powder: 12-24 months frozen Reconstituted with bacteriostatic water: 4-6 weeks refrigerated Reconstituted with sterile water: 72 hours refrigerated After first puncture: Follow bacteriostatic water guidelines Discard if discoloration or particles appear Monitoring Solution Integrity Inspect reconstituted solutions before each use
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