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Toxic solvent residues DMF (dimethylformamide) Known liver toxin Associated with reproductive toxicity Must be removed to extremely low limits in GMP drugs DCM (dichloromethane / methylene chloride) Probable human carcinogen Central nervous system depressant Dangerous even in small amounts if injected TFA (trifluoroacetic acid) Corrosive Can remain in peptides as unmeasured TFA salt Pharmaceutical products often convert TFA salts to safer counterions Without validated HPLC, mass spectrometry, and residual solvent testing, patients may be injected with harmful chemical contaminants
In addition, two homologs, GGTLC1 (previously GGTL6, GGTLA4) and GGTLC2, which may only encode the light-chain portion of GGT, as well as at least three other homologs, exhibit activity: GGT5 (formerly GGL, GGTLA1/GGT-rel), GGT6 (formerly rat GGT6 homologous) and GGT7 (formerly GGTL3, GGT4) (28)
10.1016/j.ab.2016.12.022 7
Despite its growing popularity in biohacking circles and advanced longevity practitioners, Epitalons long-term safety remains unclear: No large-scale toxicology or pharmacokinetic studies in humans have been published
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