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The medication's central nervous system effects may also play a role, though this mechanism is hypothetical
The MHRA update also complements the recent consensus statement from anaesthetic and specialist organisations that provides guidance for how the increased risk can be managed safely in the perioperative period. In early January 2025, the Association of Anaesthetists published a multidisciplinary consensus statement on elective peri-operative management of adults taking GLP-1 and dual GIP/GLP-1 RAs, which advised that patients take GLP-1 or dual GIP/GLP-1 RAs as normal, as well as receive a full risk assessment and peri-operative techniques to mitigate risk of pulmonary aspiration during the peri-operative period
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GLP-1s in Midlife the Hormone Therapy Connection Animal research suggests that GLP-1 hormones have different effects in males and females, with females being more sensitive to GLP-1 receptor activation
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