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The kynurenine pathway is the principal route of tryptophan metabolism, accounting for the degradation of over 95% of tryptophan into various bioactive compounds
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Furthermore, when apoptosis and necroptosis fail to occur, caspase-8 can be involved in the activation of caspase-1 and inflammasome to trigger pyroptosis, a strongly proinflammatory cell death modality associated with the release of IL-1 and IL-18 [145, 146]
Rais, N., Ved, A., Shadab, M., Ahmad, D
In the five in vitro studies, although a decrease in the apoptosis rate of granulosa cells was observed at specific doses, it was not confirmed whether this effect could translate into an improvement in oocyte quality in vivo (Fabov et al., 2023
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