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GLP-1RAs exert glycemic control through multiple mechanisms, including the stimulation of insulin secretion under hyperglycemic conditions, suppression of glucagon secretion during hyperglycemia, deceleration of gastric emptying to mitigate postprandial glucose spikes, reduction of caloric intake, and promotion of weight loss
After 3 months of treatment with Tioneural retard, patients reported a statistically significant reduction in neuralgic pain measured with the VAS scale (-62.3%)
By combining the activities of GLP-1 and E2, we envisioned synergistic insulinotropic activities of these molecules on -cells
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