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When a GLP-2 is added to a patients regimen, it is critical to monitor blood glucose and more specifically, watch out for hypoglycemia
171 GWAS in major populations consistently highlight urate transporter genes as pivotal loci influencing serum uric acid levels, 138,139 notably SLC2A9 (GLUT9) and SLC22A12 (URAT1), involved in urate reabsorption from urinary filtrates
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In trials with secondary endpoints, such as STEP 9 [38], semaglutide also resulted in significant improvements in obesity-related comorbidities, including osteoarthritis-related pain and rates of reversion to normoglycaemia, further underscoring its broad clinical utility