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An early clinical appraisal of ICI46474
Role of central glucagon-like peptide-1 in stress regulation
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There is no official FDA black box warning specifically linking tirzepatide to gallstones , but the prescribing information for both Mounjaro and Zepbound includes warnings about acute gallbladder disease, noting that cholelithiasis (gallstones) and cholecystitis (gallbladder inflammation) were observed in clinical trials
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