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Previous studies have shown that thapsigargin-induced ER stress increases SREBP2 levels in Huh-7 hepatocytes (14)
Its findings, published recently in the American Journal of Ophthalmology , revealed a notable correlation between semaglutide, the most commonly prescribed GLP-1 RA, and increased incidents of ischemic optic neuropathy, diabetic retinopathy and several other retinal and vitreous issues
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It's unclear why, specifically, either of these are the case
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