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Glycosaminoglycan synthesis also increased by approximately 70%, contributing to improved skin hydration and volume

The frequency of B12 injections varies depending on the underlying cause of deficiency, the severity of symptoms, and whether neurological complications are present

Before this meta-analysis, the IM route was generally the preferred route, but our results showed that no route is usually preferred, and SL and oral routes should be considered comparable alternative routes

The medical team should explain whether a recommended treatment is established, off-label, compounded, or investigational

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