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55 Indeed, a more recent large meta-analysis confirmed that while GIPR variants may influence BMD, this does not necessarily translate to increased bone fracture risk
Sam Hawley: All right, well, Paul, I have seen that these drugs have been described as miracle drugs
When GLP-1 receptors in the brain, particularly the hypothalamus, are activated, it leads to increased feelings of fullness (satiety)
That's not a rounding error
A 2024 analysis suggested 13% additional weight loss in GLP-1 plateau patients when topiramate was added, but adverse-event rates were higher
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