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Until then, the most accurate answer is: Retatrutide is the higher-upside candidate, while CagriSema is the more incremental combination strategy

Furthermore, the active ingredient in Wegovy has been approved for reducing the risk of major adverse cardiovascular events in adults with existing heart disease, adding an extra layer of benefit for certain patients

Of interest, the subgroup analysis showed that semaglutide reduced the risk of atrial arrhythmias and AF by 36% and 38%, respectively, while no anti-arrhythmic effect was observed among the other GLP-1RAs (79)

* Obesity

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