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(2024) SARS-CoV-2 virulence factor ORF3a blocks lysosome function by modulating TBC1D5-dependent Rab7 GTPase cycle

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34 In summary, unlike in clinical studies, and, although transient biological changes can be detected, disc trauma without loss of nucleus tissue or nucleus herniation and without endplate impairment so far has not shown to promote disc degeneration in biological models