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Researchers consulting recent reviews (PMID 41966639) should attend to the regulatory framing as much as the mechanism framing

This approach helps identify individual tolerance thresholds and minimises gastrointestinal side effects

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The table lists mild to moderate nausea in 40-50% of people as the expected gastrointestinal adjustment, and attributes the variation to gastric emptying rate, GIP receptor pathway sensitivity, and prior gastrointestinal tolerance