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Compare this to short-acting GLP-1 agents with half-lives of hours, which require daily or twice-daily dosing
No serious adverse events were recorded [6]
Semaglutide GLP-1 activates GLP-1 receptors in the brain, which leads to a decrease in the activity of the hunger center
The combined effect may contribute to faster improvements in metabolic markers like insulin sensitivity , blood pressure, and lipid profiles
SAEs were less common with oral semaglutide 14 mg (47.9%) than with placebo (50.3%), although there was a higher incidence of gastrointestinal disorders with oral semaglutide 14 mg (5.0% versus 4.4%)
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