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In rare cases, they can cause more serious side effects such as: Pancreatitis (inflammation of the pancreas) Hypoglycemia (low blood sugar) Kidney problems Gallbladder problems Allergic reactions Patients should seek immediate medical attention if they experience symptoms such as severe abdominal pain, persistent nausea or vomiting, rapid heartbeat, difficulty breathing, or swelling of the face, lips, tongue, or throat

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The review delves into the intricacies of different modification approaches, including N and C-terminal modifications, Fatty acid Side chain Modifications, and Large Molecule Conjugation Modifications, highlighting their rationale and resulting improvements in half-life, stability, receptor binding, and bioactivity